Applied Blue Biotechnology Master Home Sciences, Technologies and Health Applied Blue Biotechnology Master Add to my courses download this page in Simplified version (3 pages - 152.9 kb) download this page in Detailed version (7 pages - 168 kb) OBJECTIVES ADMISSION PROGRAMME AFTERWARDS Identity card Domain : Sciences, Technologies and Health Full time course Continuing Education Degree apprenticeships 60 ECTS credits 2 semesters Course taught in English La Rochelle In partnership with This master is part of the project "A blue Biotechnolgy Master for a Blue Career" cofunded by the program “European Maritime and Fisheries Fund” (EMFF) of the European Union OBJECTIVES Presentation The aim of the program is to prepare students for employment in the blue biotechnology industries, including aquaculture, nutrition and health sectors. Stéphanie Bordenave-Juchereau ADMISSION Your profile A min of 240 ECTS is required to apply to this second year of master. Graduates of recognized academic institutions outside France should hold an appropriate degree in biological sciences (biochemistry, biotechnology, marine sciences) to demonstrate their academic potential to the Admission Committee How to apply ? The Admission Committee will evaluate the application form submitted Link for Application form: https://www.univ-larochelle.fr/s-inscrire-master-2 PROGRAMME PROGRAMME OBJECTIVES During this programme students will: Gain practical experience and knowledge of biochemical, molecular and bioinformatic approaches important for a career in the blue economy Apply newly-acquired knowledge to identify and develop solutions for optimal use and protection of our marine environment to underpin the sustainable expansion of the blue economy Understand how biotechnology can help to address challenges facing marine-based industries, particularly those that culture aquatic organisms Understand the process of discovering and developing molecules derived from and inspired by marine organisms as new products to meet consumer needs in various markets Obtain insight into business opportunity development and the commercial realities faced by industry, through experiences shared by successful marine biotechnology entrepreneurs Undertake a significant component of bespoke workplace-based training to augment key employability skills acquired during the course. fold all unfold all Semester 3 Assays in Marine Biotechnology Assays : targets and dysfunction mitigation strategies [Course taught in English] Learning outcomes Students will learn to optimize and transfer assays from in vitro to ex vivo and in vivo. Content Introduction: assays in blue biotechnology, IC50 definition, threshold, controls. Student will first learn how to perform various assays: using reactions, enzymes (measurement of inhibition or increase of activity), organites, cells (eukaryotes, prokaryotes), tissues, animals, humans. Part 1: Target of an assay: what kind of biological activity can be assessed for human nutrition and health (metabolic syndrome (dyslipidemia, arterial hypertension, obesity, diabetes) ) cancer (angiogenesis, cell cancerization, apoptosis), skin health, ageing, oxidative stress. Part 2: Target of an assay in the aquaculture domain, growth parameters, mortality, color, digestive activity, reproduction, welfare indicators. Language used for teachingEnglish 12h (12h lectures) 2 ECTS credits Course codeC2-279331-BIOT New assay development [Course taught in English] Learning outcomes Students will learn to design new assays to test and identify new biological activities. Content Braistorm of biological activities lacking assays. Applications focused on human health and aquaculture Students will also learn about how to improve bioavailability and the metabolism of molecules in living organisms Language used for teachingEnglish 12h (12h lectures) 2 ECTS credits Course codeC2-279332-BIOT Experience and validate assays [Course taught in English] Learning outcomes Students will conduct assays and process data. Content Part 1: Methods for handling MNPs Extraction and fractionation Research-scale extraction and fractionation methods Industrial-scale extraction and fractionation methods Analysis of MNPs HPLC Mass spectrometry Advanced topics: elicitation, biological engineering, co-culturing Elicitation Biological engineering Co-culturing Part 2: Relevance/performance of assays in blue biotechnology , economical evaluation/cost calculation of assays Part 3: Practice Sampling and extraction of marine organism. Antimicrobial (cell scale) and antihypertensive assays (enzyme scale) will be performed. The angiotensin I converting enzyme, which is a key enzyme in the control of arterial hypertension, will be used as a model all along the practical course. Various substrates (natural, synthetic), enzyme sources (human, animal, extracts) and analytical material (spectrophotometer, spectrofluorimeter, RP-HPLC) will be tested to understand how far such parameters can modify results of the test. Pure known molecules as well as various extracts and hydrolysates will be tested. Data obtained will be statistically analysed. Language used for teachingEnglish 39h (9h lectures - 30h practical work) 2 ECTS credits Course codeC2-279333-BIOT Culture of marine organisms Biodiversity in the seas [Course taught in English] Learning outcomes Students will learn how to collect, isolate and identify marine organisms (microorganisms, fish, algae, etc.) Content During this course, student will be able to: Provide an overview of the biological diversity of the organisms that prosper in our oceans, including viruses, prokaryotes, microbial eukaryotes and larger organisms; Demonstrate understanding for how our unique marine genetic resources can be a rich source of valuable products and processes to be applied to various market opportunities; Describe some of the approaches taken to collect, identify and harness the potential of the organisms in our seas. Language used for teachingEnglish 15h (15h lectures) 2 ECTS credits Course codeC2-279341-BIOT Introduction to aquaculture [Course taught in English] Learning outcomes Students will acquire an overview of all culture systems developed for aquaculture and will learn how to use skillfully culture systems of marine organisms (microorganisms, fish, algae, etc.) in compliance with the relevant safety and environmental requirements_Practical courses will allow student to experience marine organism culture plan, develop and innovate in different kind of marine organism cultures, including scaling-up. Language used for teachingEnglish 30h (9h lectures - 21h tutorials) 2 ECTS credits Course codeC2-279342-BIOT Challenges and opportunities in aquaculture TEST [Course taught in English] Learning outcomes Students will become familiar with the breeding strategies of various species and will be able to develop captive-bred species development programs (fish, etc.). Content At the end of this module, students will be able to: Appreciate the role of blue biotechnology in addressing ongoing and future challenges in the culture of marine organisms to meet global demand for nutritious food; Describe specific challenges driving innovation in aquaculture, particularly around diseases, genetic improvement and the feed requirements of aquatic organisms; Explain some of the broader considerations around legal, social and environmental acceptability when collecting and culturing marine organisms. Language used for teachingEnglish 15h (15h lectures) 2 ECTS credits Course codeC2-279343-BIOT Employability Communication [Course taught in English] Learning outcomes Students will practice at least two other languages than English and mother tongue to be able to integrate a blue biotechnology team in Europe. Students will learn to convey ideas through a range of media. Language used for teachingEnglish 24h (24h tutorials) 2 ECTS credits Course codeDC-279301-COM Working in foreign countries [Course taught in English] Learning outcomes Students will develop a background knowledge of some of the problems that marine biotechnology can address;_Students will have an appreciation for commercialization and entrepreneurship and the roles that these play in marine biotechnology. They will also know the rules of intellectual properties._They will learn how to apply for a job opportunity in a foreign country. Content Students will learn: How to run a company Entrepreneurship Product development Business game Intellectual property How to Apply for a job opportunity in foreign countries Language used for teachingEnglish 15h (15h lectures) 2 ECTS credits Course codeC2-279302-ODP Budget, plan, perform and report a project [Course taught in English] Learning outcomes Students will budget a biotechnological process, a project, contrast and validate results obtained in a project. They will learn how to write a research grant application and report, as well as how to present a project adequately. Language used for teachingEnglish 15h (15h lectures) 2 ECTS credits Course codeC2-279303-ODP Molecules from Aquatic Origin Marine Natural Products [Course taught in English] Learning outcomes Students will acquire an in-depth knowledge of the metabolites content of marine organisms and will learn how to improve macromolecules bioavailability. Content Marine bioresources and marine natural products The oceans as our last biodiversity frontier Biodiversity and chemodiversity Bioprospection and the Nagoya Protocol Chemically-rich marine organisms Actinobacteria Cyanobacteria Microalgae Macroalgae Invertebrates Structural classes of MNPs (and their biosynthesis) Lipids Peptides Terpenes Alkaloids Hybrids Other Language used for teachingEnglish 15h (15h lectures) 2 ECTS credits Course codeC2-279311-BIOT Biological Activities of Marine Natural Products [Course taught in English] Learning outcomes Students will acquire an understanding of the metabolism of molecules in marine organisms. Content Bioactivities : Antibacterial Antifungal Antimalarial Anti-inflammatory Anti-ageing Anti-obesity Pain relief Other Biotechnologically- and ecologically-relevant MNP bioactivities Antifouling Cosmetic Nutraceutical / Nutritional Research tools Monitored toxins Emergent toxins Biotechnological processes and Marine Natural Products Language used for teachingEnglish 15h (15h lectures) 2 ECTS credits Course codeC2-279312-BIOT The Marine Biotechnology Pipeline [Course taught in English] Learning outcomes Students will acquire knowledge of specific needs for human population (elderly, sportsmen) and will learn how to integrate marine molecules in innovative products to correct physiological dysfunctions Content Overview (discovery, development and supply issues) Case studies: conopeptides, MAAs, Seattle Genetics SME¿s conferences Language used for teachingEnglish 15h (15h lectures) 2 ECTS credits Course codeC2-279313-BIOT Omics approaches Genomics and other Omics [Course taught in English] Learning outcomes Students will work on understanding the principles governing `omics technologies : genomics, metagenomics, transcriptomics, proteomics and metabolomics, and will perform the basics of a data analysis workflow for `Omics expression data. Content Introduction to Omics Genomics: genome structure and organization, Next Generation Sequencing (NGS) techniques for genome sequencing. Marine Metagenomics Global analysis of gene expression and transcriptome profiling: qRT-PCR, microarrays, RNA-seq. Introduction to Systems Biology: approaches and metabolic network analysis; network modelling. Proteomics workflow: experimental design, sample preparation, data acquisition and data analysis. Differential expression proteomics and protein interaction approaches. Language used for teachingEnglish 15h (15h lectures) 2 ECTS credits Course codeC2-279321-BIOT Bioinformatics [Course taught in English] Learning outcomes Students will use `Omics approaches to explore microbial communities and to explore biotechnological benefits of marine ecosystems Content Bioinformatics databases and sequence alignment tools Introduction to molecular evolution and phylogeny Basic computational skills for genomic and metagenomic analysis Protein databases and modelling Language used for teachingEnglish 15h (15h lectures) 2 ECTS credits Course codeC2-279322-BIOT Experience Omics [Course taught in English] Learning outcomes Student will practice `Omics to increase their laboratory skills. Content After the completion of this course, students will be able to perform several fundamental laboratory techniques used for Genomics and Proteomics analyses, such as Next Generation Sequencing library preparation and 2-D electrophoresis analysis. Language used for teachingEnglish 30h (9h lectures - 21h practical work) 2 ECTS credits Course codeC2-279323-BIOT Semester 4 Work place based training Work place based training [Course taught in English] Learning outcomes During this work place base training, students will experience one or more research project(s) dealing with blue biotechnology. Language used for teachingEnglish 30 ECTS credits Course codeC2-279411-STAG AFTERWARDS Activity areas Biology, biotechnologies