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Applied Blue Biotechnology Master

Carte d'identité de la formation

  • Field : Science, Technology, Health
  • Initial training
  • Continuing training

In partnership with

This master is part of the project "A blue Biotechnolgy Master for a Blue Career" cofunded by the program “European Maritime and Fisheries Fund” (EMFF) of the European Union

OBJECTIVES

Knowledge

The aim of the program is to prepare students for employment in the blue biotechnology industries, including aquaculture, nutrition and health sectors.

Targeted skills

  • Gain practical experience and knowledge of biochemical, molecular and bioinformatic approaches important for a career in the marine biotechnology sector
  • Apply knowledge acquired to provide solutions for challenges in the marine environment including understadning for the need to protect these habitats
  • Understand how biotechnology can help address challenges facing marine-based industries that culture aquatic organisms to underpin the future expansion of the blue economy
  • Understand the process of discovering and developing marine-derived and inspired molecules as new products for various markets including products improve human health and wellbeing
  • Insight into business opportunities, commercial realities and challenges faces by indstrial enterprises through experiences shared by successful marine biotechnology entrepreneurs
  • Undertake significant component of workplace based training to augment employability skills aquired during the course

ADMISSION

Prerequisites

A min of 240 ECTS is required to apply to this second year of master.
Graduates of recognized academic institutions outside France should hold an appropriate degree in biological sciences (biochemistry, biotechnology, marine sciences) to demonstrate their academic potential to the Admission Committee

Registration details

The Admission Committee will evaluate the application form submitted
Link for Application form : http://www.univ-larochelle.fr/Candidater-en-2eme-annee-de-master

PROGRAMME

PROGRAMME OBJECTIVES :
During this programme students will :

  • Gain practical experience and knowledge of biochemical, molecular and bioinformatic approaches important for a career in the blue economy
  • Apply newly-acquired knowledge to identify and develop solutions for optimal use and protection of our marine environment to underpin the sustainable expansion of the blue economy
  • Understand how biotechnology can help to address challenges facing marine-based industries, particularly those that culture aquatic organisms
  • Understand the process of discovering and developing molecules derived from and inspired by marine organisms as new products to meet consumer needs in various markets
  • Obtain insight into business opportunity development and the commercial realities faced by industry, through experiences shared by successful marine biotechnology entrepreneurs
  • Undertake a significant component of bespoke workplace-based training to augment key employability skills acquired during the course.
  • Learning outcomes

    During this course, student will learn how to propose and optimise assays

  • Content

    Introduction : assays in blue biotechnology, IC50 definition, threshold, controls.
    Student will first learn how to perform various assays : using reactions, enzymes (measurement of inhibition or increase of activity), organites, cells (eukaryotes, prokaryotes), tissues, animals, humans.
    Part 1 : Target of an assay : what kind of biological activity can be assessed for human nutrition and health (metabolic syndrome (dyslipidemia, arterial hypertension, obesity, diabetes) ) cancer (angiogenesis, cell cancerization, apoptosis), skin health, ageing, oxidative stress.
    Part 2 : Target of an assay in the aquaculture domain,
    growth parameters, mortality, color, digestive activity, reproduction, welfare indicators.

  • Language used for teaching

    English

  • 12h (12h lectures)
  • 2 ECTS credits
  • Course code

    C2-279331-BIOT

  • Learning outcomes

    During this course, student will learn about methods to handle MNPs, perform some assays and treat data obtained from such assays

  • Content

    Part 1 : Methods for handling MNPs
    Extraction and fractionation
    Research-scale extraction and fractionation methods
    Industrial-scale extraction and fractionation methods
    Analysis of MNPs
    HPLC
    Mass spectrometry
    Advanced topics : elicitation, biological engineering, co-culturing
    Elicitation
    Biological engineering
    Co-culturing
    Part 2 : Relevance/performance of assays in blue biotechnology , economical evaluation/cost calculation of assays
    Part 3 : Practice
    Sampling and extraction of marine organism.
    Antimicrobial (cell scale) and antihypertensive assays (enzyme scale) will be performed.
    The angiotensin I converting enzyme, which is a key enzyme in the control of arterial hypertension, will be used as a model all along the practical course. Various substrates (natural, synthetic), enzyme sources (human, animal, extracts) and analytical material (spectrophotometer, spectrofluorimeter, RP-HPLC) will be tested to understand how far such parameters can modify results of the test. Pure known molecules as well as various extracts and hydrolysates will be tested. Data obtained will be statistically analysed.

  • Language used for teaching

    English

  • 39h (9h lectures - 30h practical work)
  • 2 ECTS credits
  • Course code

    C2-279333-BIOT

  • Learning outcomes

    During this course, student will learn how to propose novel assays to identify new biological activities.

  • Content

    Braistorm of biological activities lacking assays.
    Applications focused on human health and aquaculture
    Students will also learn about how to improve bioavailability and the metabolism of molecules in living organisms

  • Language used for teaching

    English

  • 12h (12h lectures)
  • 2 ECTS credits
  • Course code

    C2-279332-BIOT

  • Learning outcomes

    During this course, student will be able to :
    Provide an overview of the biological diversity of the organisms that prosper in our oceans, including viruses, prokaryotes, microbial eukaryotes and larger organisms ;
    Demonstrate understanding for how our unique marine genetic resources can be a rich source of valuable products and processes to be applied to various market opportunities ;
    Describe some of the approaches taken to collect, identify and harness the potential of the organisms in our seas.

  • Language used for teaching

    English

  • 15h (15h lectures)
  • 2 ECTS credits
  • Course code

    C2-279341-BIOT

  • Learning outcomes

    At the end of this module, students will be able to :
    Appreciate the role of blue biotechnology in addressing ongoing and future challenges in the culture of marine organisms to meet global demand for nutritious food ; Describe specific challenges driving innovation in aquaculture, particularly around diseases, genetic improvement and the feed requirements of aquatic organisms ;
    Explain some of the broader considerations around legal, social and environmental acceptability when collecting and culturing marine organisms.

  • Language used for teaching

    English

  • 15h (15h lectures)
  • 2 ECTS credits
  • Course code

    C2-279343-BIOT

  • Learning outcomes

    At the end of this module, students will be able to :
    Describe systems used to cultivate common marine organisms for food and non-food products, including algae, fish and invertebrates ;
    Recognise the scale and extent of aquaculture across Europe and elsewhere, including an overview of value chains and knowledge of the key challenges facing these industries.

  • Language used for teaching

    English

  • 30h (9h lectures - 21h tutorials)
  • 2 ECTS credits
  • Course code

    C2-279342-BIOT

  • Learning outcomes

    During this course, student will budget a biotechnological process, a project, a feed formulation
    contrast and validate results obtained in a project.
    Working with data (types, analysis, organisation, stats)
    how to develop a research grant application
    Report and present in adequate manner a project
    Critical reading, lab note books, records.

  • Language used for teaching

    English

  • 15h (15h lectures)
  • 2 ECTS credits
  • Course code

    C2-279303-ODP

  • Learning outcomes

    During this course, student will learn some words of at least two other languages than English and mother tongue to be able to integrate a blue biotechnology team in Europe. Student will learn to convey ideas through a range of media.

  • Language used for teaching

    English

  • 24h (24h tutorials)
  • 2 ECTS credits
  • Course code

    DC-279301-COM

  • Learning outcomes

    Students will have an appreciation for commercialization and entrepreneurism and the roles that these play in marine biotechnology and achieve a basic understanding of intellectual property and its value.

  • Content

    Students will learn :
    How to run a company
    Entrepreneurship
    Product development
    Business game
    Intellectual property
    To Apply to a job opportunity in foreign country

  • Language used for teaching

    English

  • 15h (15h lectures)
  • 2 ECTS credits
  • Course code

    C2-279302-ODP

  • Learning outcomes

    During this course, students will study showcase of pharmacologically-relevant MNP bioactivities.

  • Content

    Bioactivities :
    Antibacterial
    Antifungal
    Antimalarial
    Anti-inflammatory
    Anti-ageing
    Anti-obesity
    Pain relief
    Other
    Biotechnologically- and ecologically-relevant MNP bioactivities Antifouling
    Cosmetic
    Nutraceutical / Nutritional
    Research tools
    Monitored toxins
    Emergent toxins
    Biotechnological processes and Marine Natural Products

  • Language used for teaching

    English

  • 15h (15h lectures)
  • 2 ECTS credits
  • Course code

    C2-279312-BIOT

  • Learning outcomes

    During this course student will acquire in-depth knowledge of the metabolites produced by marine organisms.

  • Content

    Marine bioresources and marine natural products
    The oceans as our last biodiversity frontier
    Biodiversity and chemodiversity
    Bioprospection and the Nagoya Protocol
    Chemically-rich marine organisms
    Actinobacteria
    Cyanobacteria
    Microalgae
    Macroalgae
    Invertebrates
    Structural classes of MNPs (and their biosynthesis)
    Lipids
    Peptides
    Terpenes
    Alkaloids
    Hybrids
    Other

  • Language used for teaching

    English

  • 15h (15h lectures)
  • 2 ECTS credits
  • Course code

    C2-279311-BIOT

  • Learning outcomes

    During this course, student will study cases with teachers and professionals.

  • Content

    Overview (discovery, development and supply issues)
    Case studies : conopeptides, MAAs, Seattle Genetics
    SME¿s conferences

  • Language used for teaching

    English

  • 15h (15h lectures)
  • 2 ECTS credits
  • Course code

    C2-279313-BIOT

  • Learning outcomes

    Students will acquire the computational tools needed to be able to study biological systems, as well as the use on online databases to access to the relevant biological data.

  • Content

    Bioinformatics databases and sequence alignment tools
    Introduction to molecular evolution and phylogeny
    Basic computational skills for genomic and metagenomic analysis
    Protein databases and modelling

  • Language used for teaching

    English

  • 15h (15h lectures)
  • 2 ECTS credits
  • Course code

    C2-279322-BIOT

  • Learning outcomes

    After the completion of this course, students will be able to perform several fundamental laboratory techniques used for Genomics and Proteomics analyses, such as Next Generation Sequencing library preparation and 2-D electrophoresis analysis.

  • Content

    Genomics : Next Generation Sequencing library preparation, quality control and validation.
    Basic proteomics laboratory : protein 2-D electrophoresis.

  • Language used for teaching

    English

  • 30h (9h lectures - 21h practical work)
  • 2 ECTS credits
  • Course code

    C2-279323-BIOT

  • Learning outcomes

    During this course, student will gain insight into the principles governing ¿Omics¿ approaches : Genomics, Metagenomics, Transcriptomics, Proteomics and Metabolomics, learning the basic experimental and data analysis workflows for these domains.

  • Content

    Introduction to Omics
    Genomics : genome structure and organization, Next Generation Sequencing (NGS) techniques for genome sequencing.
    Marine Metagenomics
    Global analysis of gene expression and transcriptome profiling : qRT-PCR, microarrays, RNA-seq.
    Introduction to Systems Biology : approaches and metabolic network analysis ; network modelling.
    Proteomics workflow : experimental design, sample preparation, data acquisition and data analysis. Differential expression proteomics and protein interaction approaches.

  • Language used for teaching

    English

  • 15h (15h lectures)
  • 2 ECTS credits
  • Course code

    C2-279321-BIOT

  • Learning outcomes

    During this work place base training, students will experience one or more research project(s) dealing with blue biotechnology.

  • Language used for teaching

    English

  • 30 ECTS credits
  • Course code

    C2-279411-STAG

AFTERWARDS

Activity areas

  • Biology, biotechnology

Faculté des Sciences et Technologies

avenue Michel Crépeau

17042 La Rochelle cedex 1

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Mis à jour le 28 juin 2017
Informations présentées sous réserve de modifications